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This sudden lengthening may lead to micro- or macro-tears of the crosslinks that bind the fibers together or even to the fibers themselves

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CagriSema — a fixed-ratio, once-weekly combination of the long-acting amylin analog cagrilintide and the GLP-1 receptor agonist semaglutide — has produced some of the largest weight reductions ever recorded in obesity trials, and because excess liver fat is tightly coupled to body weight, researchers are asking whether that combination could also reshape the trajectory of obesity-related liver disease